What is VIP?
VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide with diverse biological functions including vasodilation, immune modulation, neuroprotection, and regulation of smooth muscle activity. It is naturally produced throughout the body and acts as both a neurotransmitter and hormone.
VIP has attracted significant research interest for conditions including CIRS (Chronic Inflammatory Response Syndrome), particularly in the context of mold illness protocols.
Natural Functions
Physiological Roles
Cardiovascular:
- Vasodilation
- Blood pressure regulation
- Coronary artery dilation
Immune:
- Anti-inflammatory effects
- Immune cell modulation
- Cytokine regulation
Neurological:
- Neuroprotection
- Circadian rhythm regulation
- Memory and learning
Gastrointestinal:
- Smooth muscle relaxation
- Secretion regulation
- GI motility
Molecular Profile
Structure
28-amino acid peptide:
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
| Property | Value |
|---|---|
| Amino Acids | 28 |
| Molecular Weight | ~3326 Da |
| Half-life | 1-2 minutes (blood) |
Research Applications
CIRS Research
VIP has been studied in:
- Mold illness protocols
- Inflammatory regulation
- Shoemaker protocol applications
Other Research
- Neuroprotection
- Autoimmune conditions
- GI disorders
- Circadian research
Summary
VIP is a multifunctional neuropeptide with broad physiological effects, currently of interest in inflammatory and immune research.
Key Points:
- Classification: Endogenous neuropeptide
- Functions: Vasodilation, immune, neuro
- Research: CIRS, inflammation, neuroprotection
- Status: Naturally occurring, research applications