Vilon (Lys-Glu) is recognized as one of the shortest bioactive peptides known with significant biological activity, developed by Professor Vladimir Khavinson.
Structure
Amino Acid Sequence: Lys-Glu (Lysine-Glutamic acid)
At just two amino acids, Vilon represents the minimal peptide length with measurable biological effects.
Chromatin Remodeling
Research demonstrates Vilon induces:
- Activation of synthetic processes through ribosomal gene reactivation
- Deheterochromatinization (unrolling) of condensed chromatin
- Release of repressed genes from facultative heterochromatin
This is pronounced in lymphocytes from elderly individuals.
Telomere Effects
Normalizes telomere length in stimulated lymphocyte cultures. Increases euchromatin proportion while decreasing heterochromatin.
Gene Expression
Regulates aging-related genes:
- IGF1, FOXO1, TERT, NFκB
Immune System Effects
In irradiated animals:
- Enlarged thymic lobules
- Increased proliferating cells (26% → 37%)
- Upregulated CD5 expression (T-cell maturation)
Anti-Aging & Anti-Tumor Effects
- Increased lifespan in aged mice
- Improved physical endurance
- Reduced spontaneous tumor incidence
- Strong dose-dependent inhibition of tumor cell proliferation (not normal leukocytes)