What is Syn-Coll?
Syn-Coll (Palmitoyl Tripeptide-5) is a collagen-stimulating peptide that mimics the body's natural mechanism for activating collagen synthesis. It works by activating the TGF-β pathway, which signals fibroblasts to produce collagen, resulting in firmer, more youthful skin.
Developed by Pentapharm, Syn-Coll represents a targeted approach to boosting collagen production through signaling mimicry.
Mechanism of Action
TGF-β Pathway Activation
Syn-Coll stimulates collagen through:
- Mimics thrombospondin-1 signal
- Activates TGF-β receptor
- Signals fibroblasts
- Increases collagen synthesis
- Improves skin matrix
Types of Collagen Affected
- Collagen I (primary skin collagen)
- Collagen III (supporting structure)
- Overall matrix improvement
Molecular Profile
Structure
Palmitoyl-Lys-Val-Lys (Pal-KVK)
| Property | Value |
|---|---|
| Type | Lipopeptide |
| Modification | Palmitoyl (C16) |
| Target | TGF-β signaling |
Clinical Evidence
Research shows:
- Increased collagen synthesis
- Improved skin firmness
- Wrinkle depth reduction
- Enhanced skin elasticity
- Optimal concentration: 4%
Comparison with Other Collagen Peptides
| Peptide | Mechanism | Effect |
|---|---|---|
| Syn-Coll | TGF-β activation | Collagen synthesis |
| Matrixyl | Matrikine signaling | Matrix repair |
| GHK-Cu | Multi-pathway | Broad regeneration |
Summary
Syn-Coll provides targeted collagen stimulation through TGF-β pathway activation, offering a specific approach to addressing collagen loss in aging skin.
Key Points:
- Classification: Collagen-stimulating lipopeptide
- Mechanism: TGF-β pathway activation
- Effect: Increased collagen synthesis
- Use: Anti-aging, firmness improvement