What is Syn-Ake?
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic peptide that mimics the effect of Waglerin-1, a component of Temple Viper venom. It works by inhibiting muscle contractions through a different mechanism than Argireline, specifically targeting muscular nicotinic acetylcholine receptors.
Developed by Pentapharm, Syn-Ake offers a "snake venom-inspired" approach to reducing expression lines.
Mechanism of Action
Nicotinic Receptor Antagonism
Syn-Ake works differently than SNARE-modulating peptides:
- Mimics waglerin-1 activity
- Binds muscular nicotinic receptors
- Reduces receptor activation
- Decreases muscle contraction frequency
- Smooths expression lines
Comparison with Other Approaches
| Peptide | Target | Mechanism |
|---|---|---|
| Syn-Ake | nAChR | Receptor antagonism |
| Argireline | SNARE | Complex inhibition |
| Leuphasyl | Enkephalin | Receptor activation |
Molecular Profile
Structure
Synthetic tripeptide mimetic:
- Diaminobutyric acid based
- Benzylamide component
- Diacetate salt form
Clinical Evidence
Studies show:
- 52% wrinkle reduction in 28 days (claims)
- Improved skin smoothness
- Expression line softening
- Works on forehead and crow's feet
- Recommended concentration: 4%
Summary
Syn-Ake offers a unique venom-inspired approach to anti-aging through nicotinic receptor modulation, distinct from SNARE-targeting peptides.
Key Points:
- Classification: Venom-mimetic peptide
- Inspiration: Temple Viper waglerin-1
- Target: Nicotinic acetylcholine receptor
- Use: Expression line reduction