What is SNAP-8?
SNAP-8 (Acetyl Octapeptide-3) is an extended version of Argireline with an additional two amino acids, designed to provide enhanced expression line reduction. Like Argireline, it works by modulating SNARE complex formation to reduce muscle contractions that cause wrinkles.
The longer sequence is theorized to provide better efficacy in some formulations, making it a popular choice in advanced anti-aging cosmetics.
Mechanism of Action
SNARE Complex Modulation
SNAP-8 interferes with neuromuscular transmission:
- Mimics SNAP-25 N-terminus (extended)
- Competes for SNARE complex binding
- Reduces vesicle-membrane fusion
- Decreases acetylcholine release
- Softens muscle contractions
Molecular Profile
Structure
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Comparison
| Peptide | Amino Acids | Sequence |
|---|---|---|
| Argireline | 6 | Ac-EEMQRR-NH2 |
| SNAP-8 | 8 | Ac-EEMQRRAD-NH2 |
Research Evidence
Studies demonstrate:
- Wrinkle depth reduction
- Expression line improvement
- Comparable or enhanced vs Argireline
- Safe for cosmetic use
- Optimal concentration: 3-10%
Summary
SNAP-8 offers an extended version of Argireline with potentially enhanced anti-wrinkle effects through the same neuromuscular modulation mechanism.
Key Points:
- Classification: Extended neuropeptide
- Relation: 8-amino acid version of Argireline
- Mechanism: SNARE complex interference
- Use: Expression line reduction