What is PEG-MGF?
PEG-MGF is PEGylated Mechano Growth Factor, a modified version of MGF with polyethylene glycol attached to extend its half-life. While native MGF has a very short half-life, PEGylation allows for systemic distribution and prolonged activity.
Modification
PEGylation Benefits
- Extended half-life (from minutes to hours)
- Systemic distribution possible
- Reduced immunogenicity
- More practical for research use
Trade-off
Native MGF acts locally at damage sites, while PEG-MGF may have more systemic effects, changing its biological profile.
Comparison
| Property | MGF | PEG-MGF |
|---|---|---|
| Half-life | Minutes | Hours |
| Distribution | Local | Systemic |
| Action | Autocrine | Broader |
| Research Use | Limited | More practical |
Research Applications
- Extended muscle research protocols
- Systemic effect studies
- Regenerative research
- Comparative studies with MGF
Summary
PEG-MGF offers extended half-life for MGF research at the cost of altered distribution characteristics.
Key Points:
- Classification: PEGylated MGF
- Modification: PEG attachment
- Advantage: Extended half-life
- Trade-off: Systemic vs local action