What is PE-22-28?
PE-22-28 is a synthetic peptide fragment derived from the C-terminus of human prosaposin, a protein involved in lipid metabolism and neuroprotection. It has attracted research interest for its neurotrophic and cognitive-enhancing properties.
PE-22-28 represents the active region of prosaposin responsible for many of its neuroprotective effects.
Origin
Prosaposin is a precursor protein that:
- Generates saposin proteins A-D
- Has independent neurotrophic activity
- The 22-28 region is biologically active
- PE-22-28 mimics this active fragment
Mechanism of Action
Neurotrophic Effects
PE-22-28 works through:
- GPR37 receptor activation
- Neurite outgrowth stimulation
- Neuronal survival support
- Anti-apoptotic activity
- Neuroprotection
Research Applications
Neuroprotection
- Parkinson's disease models
- Neurodegeneration research
- Neuronal survival studies
Cognitive Research
- Memory enhancement
- Neurite growth
- Brain repair mechanisms
Summary
PE-22-28 offers the neurotrophic activity of prosaposin in a defined peptide format suitable for research applications.
Key Points:
- Classification: Neurotrophic peptide
- Origin: Prosaposin fragment (22-28)
- Target: GPR37 receptor
- Status: Research compound