What is P21?
P21 is a synthetic peptide derivative of CNTF (Ciliary Neurotrophic Factor) designed to enhance neurogenesis and cognitive function. Unlike the large parent protein, P21 is a small, blood-brain barrier penetrant peptide that can stimulate neurotrophin production in the brain.
P21 represents an approach to delivering neurotrophic support through a stable, deliverable peptide format.
Development
Created as a small-molecule mimetic of CNTF activity, P21 was designed to:
- Cross the blood-brain barrier
- Remain stable
- Activate neurogenic pathways
- Be practical for research use
Mechanism of Action
Neurogenesis Promotion
P21 works through:
- Stimulates BDNF release
- Promotes neural stem cell proliferation
- Enhances hippocampal neurogenesis
- Supports cognitive function
- May provide neuroprotection
CNTF-Like Effects
Without the limitations of the large CNTF protein:
- BBB penetration
- Stability
- Practical administration
Research Applications
Cognitive Enhancement
- Memory improvement studies
- Learning enhancement
- Neuroplasticity promotion
- Age-related cognitive decline
Neurodegeneration Research
- Alzheimer's models
- Cognitive preservation
- Neuronal survival
Summary
P21 offers a practical way to study neurotrophic effects through a BBB-penetrant peptide format derived from CNTF signaling principles.
Key Points:
- Classification: Neurogenic peptide
- Origin: CNTF derivative
- Effect: BDNF stimulation, neurogenesis
- Status: Research compound