What is Nonapeptide-1?
Nonapeptide-1 is a skin-lightening peptide that inhibits melanin synthesis by blocking α-MSH binding to the MC1R receptor. Unlike other lightening agents that inhibit enzymes, it works at the receptor level to reduce the signal for melanin production.
Mechanism
MC1R Antagonism
Works by:
- Blocking α-MSH at MC1R
- Reducing melanogenesis signal
- Decreasing melanin production
- Lightening skin tone
Different from tyrosinase inhibitors—works upstream at receptor level.
Cosmetic Applications
- Hyperpigmentation treatment
- Skin brightening
- Even skin tone
- Sun damage recovery
- Age spot reduction
Comparison
| Peptide | Target | Level |
|---|---|---|
| Nonapeptide-1 | MC1R | Receptor |
| Decapeptide-12 | Tyrosinase | Enzyme |
| KPV | Inflammation | Pathway |
Summary
Key Points:
- Classification: Cosmetic lightening peptide
- Mechanism: MC1R antagonism
- Effect: Melanin reduction
- Use: Brightening, pigmentation