What is Matrixyl 3000?
Matrixyl 3000 is a combination of two matrikine peptides: Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tetrapeptide-7 (Pal-GQPR). It works by stimulating collagen production and reducing inflammation, making it one of the most researched anti-aging peptide complexes in cosmetics.
Developed by Sederma, Matrixyl 3000 has become a staple ingredient in premium anti-aging skincare products.
Composition
Two Peptides Working Together
Palmitoyl Tripeptide-1 (Pal-GHK):
- Stimulates collagen I, III, IV synthesis
- Activates TGF-β pathway
- Matrix repair signal
Palmitoyl Tetrapeptide-7 (Pal-GQPR):
- Reduces inflammation
- Decreases IL-6 production
- Anti-glycation properties
Mechanism of Action
Matrikine Signaling
Matrikines are peptides released during matrix breakdown that signal repair:
- Mimic natural matrix fragments
- Signal cells to produce collagen
- Reduce inflammatory damage
- Promote matrix remodeling
Clinical Evidence
Studies show:
- Significant wrinkle reduction
- Improved skin firmness
- Enhanced skin thickness
- Comparable to retinol in some metrics
- Well tolerated
Comparison with Other Matrix Peptides
| Peptide | Primary Effect |
|---|---|
| Matrixyl 3000 | Collagen + anti-inflammatory |
| Matrixyl | Collagen stimulation |
| GHK-Cu | Multi-pathway repair |
| Syn-Coll | Collagen mimetic |
Summary
Matrixyl 3000 provides dual-action anti-aging through collagen stimulation and inflammation reduction, making it one of the most effective cosmetic peptide complexes.
Key Points:
- Classification: Matrikine peptide complex
- Components: Pal-Tripeptide-1 + Pal-Tetrapeptide-7
- Effects: Collagen synthesis, anti-inflammatory
- Use: Anti-aging skincare