What is LL-37 Fragment?
LL-37 Fragment refers to shorter versions of the full LL-37 peptide that retain antimicrobial and immunomodulatory activity. Fragments like LL-37(17-29) have been studied for maintaining activity with easier synthesis and potentially improved stability.
Rationale
Full LL-37 challenges:
- Large size (37 amino acids)
- Expensive synthesis
- Stability concerns
Fragments offer:
- Smaller size
- Easier production
- Retained activity
Common Fragments
| Fragment | Residues | Notes |
|---|---|---|
| LL-37(17-29) | 13 aa | Active core |
| KR-12 | 12 aa | Minimal active |
| Various | Variable | Research tools |
Activity
Fragments may retain:
- Antimicrobial activity
- Immunomodulation
- Anti-biofilm effects
- Wound healing support
Summary
Key Points:
- Classification: AMP fragment
- Purpose: Simplified LL-37 analogs
- Advantage: Smaller, easier synthesis
- Activity: Variable, fragment-dependent