What is Leuphasyl?
Leuphasyl (Tyr-D-Ala-Gly-Phe-Leu) is a cosmetic peptide that mimics enkephalin to reduce muscle tension and smooth expression lines. It works through a different mechanism than Argireline, targeting opioid-like receptors rather than SNARE complexes.
Mechanism
Enkephalin Mimetic
Works by:
- Mimics natural enkephalin
- Activates enkephalin receptors
- Promotes muscle relaxation
- Reduces expression line depth
Different mechanism from SNARE-modulating peptides.
Comparison with Argireline
| Aspect | Leuphasyl | Argireline |
|---|---|---|
| Target | Enkephalin receptors | SNARE complex |
| Mechanism | Relaxation signal | Inhibit transmission |
| Effect | Expression lines | Expression lines |
May be synergistic when combined.
Cosmetic Use
- Expression line reduction
- Forehead wrinkles
- Crow's feet
- Often combined with other peptides
Summary
Key Points:
- Classification: Enkephalin-mimetic peptide
- Mechanism: Opioid receptor activation
- Effect: Muscle relaxation
- Use: Anti-wrinkle cosmetics