What is Kisspeptin-10?
Kisspeptin-10 is a decapeptide that represents the minimal active fragment of kisspeptin, a crucial hormone in regulating the reproductive axis. It activates KISS1R receptors in the hypothalamus to stimulate GnRH release, making it a powerful tool for studying fertility and puberty.
Role in Reproduction
HPG Axis Regulation
Kisspeptin is the master regulator of:
- GnRH neuron activation
- LH and FSH release
- Pubertal onset
- Ovulation
- Reproductive function
Molecular Profile
Structure
C-terminal decapeptide of kisspeptin:
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
| Property | Value |
|---|---|
| Amino Acids | 10 |
| Molecular Weight | ~1302 Da |
| Receptor | KISS1R (GPR54) |
Research Applications
Fertility Research
- Ovulation induction studies
- IVF protocols (research)
- Hypothalamic amenorrhea
- Male fertility
Puberty Research
- Precocious puberty
- Delayed puberty
- HPG axis development
Clinical Research
Clinical trials exploring:
- Alternative to hCG for ovulation trigger
- Safer fertility treatments
- Reduced hyperstimulation risk
Summary
Kisspeptin-10 offers a physiological approach to reproductive axis modulation as the natural GnRH stimulator.
Key Points:
- Classification: Reproductive neuropeptide
- Function: GnRH axis activation
- Applications: Fertility, puberty research
- Status: Research, clinical trials