Hexarelin

What is Hexarelin?

Hexarelin is a synthetic hexapeptide growth hormone secretagogue known for being the most potent GHRP in terms of growth hormone release. Developed in the 1990s, it can produce GH elevations exceeding even GHRP-2, but is also associated with more rapid desensitization and notable cardiac effects.

Beyond GH release, hexarelin has attracted significant research interest for its cardioprotective properties, mediated through both GHS-R and cardiac-specific receptors.

Research Note: Hexarelin is a research compound not approved by the FDA. Banned by WADA. Educational purposes only.

Molecular Profile

Chemical Structure

His-D-2-Methyl-Trp-Ala-Trp-D-Phe-Lys-NH2

Molecular Data

Mechanism of Action

Dual Receptor Action

Hexarelin is unique in acting through:

1. GHS-R (Ghrelin Receptor): GH release
2. CD36 Receptor: Cardiac effects

GH Release

• Strongest GH stimulation among GHRPs
• Can produce 10-20+ fold increases
• Dose-dependent response
• More prone to desensitization

Cardiac Research

Cardioprotective Effects

Hexarelin has notable cardiac properties:

• Protection against ischemic damage
• Improved cardiac output
• Effects independent of GH release
• CD36 receptor-mediated benefits

This cardiac activity distinguishes hexarelin from other GHRPs and has driven significant cardiovascular research.

Desensitization

Key Limitation

Hexarelin is more prone to desensitization:

• Reduced response with continuous use
• May require cycling protocols
• Less suitable for long-term protocols
• Other GHRPs may maintain response better

Comparison

Summary

Hexarelin stands out for maximum GH release potency and unique cardiac properties, but its tendency toward desensitization limits long-term research applications compared to other GHRPs.

Key Points:

• Classification: Most potent GHRP
• Unique Feature: Cardiac protective effects via CD36
• Limitation: More prone to desensitization
• Research Interest: Both GH and cardiovascular studies