What is Gonadorelin?
Gonadorelin is synthetic GnRH (Gonadotropin-Releasing Hormone), identical to the natural hypothalamic hormone that regulates the reproductive system. It stimulates the pituitary to release LH and FSH, making it useful for diagnostic testing and therapeutic applications.
Medical Uses
FDA-Approved Applications
- Diagnostic: Testing pituitary function
- Therapeutic: Inducing ovulation
- Research: HPG axis studies
Brand Names
- Factrel
- Lutrepulse (pulsatile)
Molecular Profile
Structure (GnRH)
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
| Property | Value |
|---|---|
| Amino Acids | 10 |
| Molecular Weight | 1182.3 Da |
| Half-life | 2-4 minutes |
Mechanism
Pituitary Stimulation
- Binds GnRH receptors
- Stimulates gonadotrophs
- LH and FSH release
- Downstream effects on gonads
Pulsatile vs Continuous
- Pulsatile: Stimulates gonadotropins
- Continuous: Downregulates (agonist effect)
Applications
- Fertility treatments
- Diagnostic testing
- Pituitary function assessment
- Research applications
Summary
Gonadorelin provides the natural signal for reproductive hormone release, useful for both diagnosis and therapy.
Key Points:
- Classification: GnRH (native sequence)
- FDA Status: Approved diagnostic/therapeutic
- Function: LH/FSH stimulation
- Key Feature: Pulsatile vs continuous effects