What is GHRP-2?
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that powerfully stimulates growth hormone release through activation of the ghrelin receptor (GHS-R). It is considered one of the most potent GHRPs available, producing robust GH secretion with a moderate side effect profile.
GHRP-2 represents an advancement over GHRP-6, offering stronger GH release with somewhat less appetite stimulation, making it a popular choice in growth hormone research.
Research Note: GHRP-2 is a research compound not approved by the FDA for human use. It is prohibited by WADA. This information is for educational purposes only.
Molecular Profile
Chemical Structure
GHRP-2 is a hexapeptide:
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Molecular Data
| Property | Value |
|---|---|
| Molecular Formula | C45H55N9O6 |
| Molecular Weight | 817.9 g/mol |
| CAS Number | 158861-67-7 |
| Half-life | ~30 minutes |
Mechanism of Action
GHS-R Activation
Like other GHRPs, GHRP-2 works through the ghrelin receptor:
- Binds GHS-R on pituitary somatotrophs
- Activates G-protein signaling
- Stimulates calcium influx
- Triggers GH release
- Suppresses somatostatin
Selectivity Profile
GHRP-2 has intermediate selectivity:
| Effect | GHRP-2 | Ipamorelin | GHRP-6 |
|---|---|---|---|
| GH Release | Very Strong | Strong | Strong |
| Hunger | Moderate | Minimal | Very Strong |
| Cortisol | Moderate | Minimal | Moderate |
| Prolactin | Some | Minimal | Some |
Research Applications
Growth Hormone Studies
- Very potent GH stimulation
- Dose-dependent response
- Synergistic with GHRH analogs
- Maintained response over time
Body Composition
- Lean mass enhancement
- Fat reduction in studies
- Protein synthesis support
Comparison with Other GHRPs
GHRP-2 is often considered the "strongest" GHRP for pure GH release, with a side effect profile between the selective ipamorelin and the non-selective GHRP-6.
Side Effects
Common:
- Moderate hunger increase
- Water retention
- Flushing
- Tingling
Hormonal:
- Some cortisol elevation
- Possible prolactin increase
Summary
GHRP-2 offers potent GH release with an intermediate selectivity profile, making it valuable for research where strong GH elevation is desired with acceptable side effects.
Key Points:
- Classification: Growth hormone releasing peptide
- GH Potency: Very strong (among strongest GHRPs)
- Hunger Effect: Moderate
- Common Use: Often combined with GHRH analogs