What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide first isolated from rabbit brain in 1977 during research into sleep-promoting substances. As its name suggests, DSIP was initially studied for its ability to induce delta wave sleep, though subsequent research has revealed a much broader range of physiological effects.
DSIP is found naturally in the brain and blood, with levels fluctuating according to circadian rhythms. Its effects extend beyond sleep to include stress modulation, pain perception, and hormone regulation.
Molecular Profile
Sequence
DSIP is a nonapeptide:
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Data
| Property | Value |
|---|---|
| Molecular Formula | C35H48N10O15 |
| Molecular Weight | 848.81 g/mol |
| CAS Number | 62568-57-4 |
| Amino Acids | 9 |
Research Areas
Sleep Research
The original focus:
- Delta wave (deep sleep) induction
- Sleep architecture effects
- Circadian rhythm modulation
- Sleep quality improvements
Stress and Adaptation
DSIP research shows:
- Stress response modulation
- Cortisol regulation
- Adaptation enhancement
- Anti-stress properties
Pain Research
Studies explore:
- Analgesic effects
- Opioid system interactions
- Pain threshold modulation
Hormone Effects
Research indicates effects on:
- LH and growth hormone
- Cortisol and ACTH
- Circadian hormone patterns
Mechanism of Action
DSIP's mechanisms remain under investigation:
- CNS receptor interactions
- Modulation of sleep centers
- Effects on neurotransmitter systems
- Stress axis regulation
Summary
DSIP extends well beyond its name, with research applications in sleep, stress, pain, and hormonal regulation.
Key Points:
- Classification: Endogenous neuropeptide
- Primary Interest: Sleep induction, stress modulation
- Status: Research compound
- Origin: Naturally occurring in brain