What is Argireline?
Argireline (Acetyl Hexapeptide-3 or Acetyl Hexapeptide-8) is a cosmetic peptide marketed as a "Botox alternative" for reducing the appearance of expression lines and wrinkles. It works by inhibiting SNARE complex formation, which reduces neurotransmitter release at the neuromuscular junction, thereby decreasing muscle contractions that cause wrinkles.
Developed by Lipotec (now part of Lubrizol), Argireline has become one of the most popular peptides in anti-aging skincare formulations.
Mechanism of Action
Neuromuscular Inhibition
Argireline mimics the N-terminus of SNAP-25:
- Competes with SNAP-25 in SNARE complex
- Inhibits vesicle-membrane fusion
- Reduces neurotransmitter release
- Decreases muscle contraction intensity
- Softens expression lines
Key Difference from Botox
| Aspect | Argireline | Botox |
|---|---|---|
| Mechanism | SNAP-25 mimetic | SNAP-25 cleavage |
| Administration | Topical | Injection |
| Effect Depth | Surface | Full paralysis |
| Potency | Mild | Strong |
| Regulation | Cosmetic | Prescription |
Molecular Profile
Structure
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Molecular Data
| Property | Value |
|---|---|
| Molecular Weight | 888.9 g/mol |
| Amino Acids | 6 |
| CAS Number | 616204-22-9 |
| INCI Name | Acetyl Hexapeptide-8 |
Clinical Evidence
Studies Show
- Reduction in wrinkle depth
- Improvement in skin smoothness
- Effects visible in 2-4 weeks
- Best results with consistent use
- Typical concentrations: 5-10%
Summary
Argireline offers a topical approach to reducing expression lines through neuromuscular modulation, providing a gentler alternative to injectable treatments.
Key Points:
- Classification: Cosmetic neuropeptide
- Mechanism: SNARE complex inhibition
- Application: Topical (creams, serums)
- Target: Expression lines and wrinkles