What is ARA-290?
ARA-290 (Cibinetide) is a tissue-protective peptide derived from erythropoietin (EPO) that lacks the hematopoietic (blood cell stimulating) effects. It acts through the innate repair receptor (IRR) to provide neuroprotection and tissue repair.
Development
Designed to capture EPO's tissue-protective effects without:
- Blood cell stimulation
- Thrombosis risk
- EPO receptor activation
Mechanism
Innate Repair Receptor
ARA-290 activates the IRR:
- Neuroprotection
- Anti-inflammatory
- Tissue repair
- Without erythropoiesis
Research Applications
- Sarcoidosis small fiber neuropathy
- Diabetic neuropathy
- Chronic pain conditions
- Tissue protection
Clinical Development
Has been in clinical trials for:
- Sarcoidosis-associated pain
- Neuropathic conditions
- Received some regulatory attention
Summary
Key Points:
- Classification: EPO-derived tissue-protective peptide
- Brand: Cibinetide
- Mechanism: Innate repair receptor activation
- Status: Clinical trials